IL-2: The Activator and Controller
Interleukin-2 (IL-2) plays a crucial role in both regulating immune responses while also maintaining peripheral self-tolerance. It acts primarily as a T cell growth factor, essential for the proliferation and survival of T cells as well as the generation of effector and memory T cells. In addition, the dual functions of IL-2 in both protective immunity and immune tolerance allows IL-2 to be a potential therapeutic in seemingly contrasting therapies, as both an immune stimulant and an immune suppressor, for cancer and autoimmune disease, respectively. InvivoGen provides the HEK-Blue™ IL-2 reporter cell line, designed to monitor IL-2 levels in a STAT5-dependent manner, for possible use in testing and studying novel less-toxic IL-2 derived molecules.